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ba0001pp225 | Cell biology: osteoclasts and bone resorption | ECTS2013

Inhibition of lipopolysacharide induced osteoclast formation and bone resorption in vitro and in vivo in mice by cystatin C

Fredrik Stralberg , Lindholm Catharina , Lindstrom Erik , Kasprzykowski Franciszek , Saftig Paul , Abrahamson Magnus , Grubb Anders , Lerner Ulf H

RANKL induced osteoclastogenesis is mediated by several transcription factors such as NF-κB, AP-1 and Nfatc1. We have found that also cysteine proteinases are involved in the signaling pathway downstream RANK. Thus, cystatin C, Z-RLVG-CHN2 (the sequence of which is based upon one of the enzyme inhibitory domains in cystatin C) and the fungal molecule E-64 inhibit RANKL induced mouse and human osteoclast formation in vitro (Strålberg et ...

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Inhibition of lipopolysacharide induced osteoclast formation and bone resorption in vitro and in vivo in mice by cystatin C

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